How the same DNA sequences can function in the three-dimensional architecture of interphase nucleus, fold in the very compact structure of metaphase chromosomes and go precisely back to the original interphase architecture in the following cell cycle

The spatial organization of chromosomes has long been connected to their polymeric nature (e.g. [1]) and is believed to be important for their biological functions, including the control of interactions between genomic elements, the maintenance of genetic

Genes are organized into discrete cellular structures called chromosomes that coordinate DNA replication and distribution of replicated genetic copies between two daughter cells. As vehicles of genetic transmission, chromosomes play a central role in