Manchester is a city in southern New Hampshire, United States. It is the most populous city in northern New England. As of the 2010 census, the city had a population of 109,565, and, in 2019, the population was estimated to be 112,673. Manchester often appears favorably in lists ranking the affordability and livability of U.S. cities, placing particularly high in small business climate, affordability, upward mobility, and education level.