Phosphodiesterase-4 inhibitor - Wikipedia
WEBA phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP). It is a member of the larger family of PDE inhibitors .
An Overview of PDE4 Inhibitors in Clinical Trials: 2010 to Early 2022
WEBAug 4, 2022 · PDE4-targeted therapy has also shown promising results in other neurological disorders and the same Rolipram, the first blood-brain-barrier permeable PDE4 inhibitor, has been proven to be effective in various animal models of Parkinson’s disease, Alzheimer’s disease, depression and neuropathic pain [159,160,161].
The Molecular Biology of Phosphodiesterase 4 Enzymes as ... - PubMed
WEBAbstract. The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a therapeutic strategy to enhance cAMP signaling in a broad range of diseases, including several types of cancers, as well as in various neurologic, …
Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory ...
WEBOct 17, 2018 · Phosphodiesterase-4 (PDE4), mainly present in immune cells, epithelial cells, and brain cells, manifests as an intracellular non-receptor enzyme that modulates inflammation and epithelial integrity. Inhibition of PDE4 is predicted to have diverse effects via the elevation of the level of cyclic adenosine monophosphate (cAMP) and the …
Role of phosphodiesterases in the pathophysiology of ... - Nature
WEBJan 7, 2021 · PDEs are divided into three groups based on their specificity to cyclic nucleotides: specific to cAMP (PDE4, PDE7, and PDE8), specific to cGMP (PDE5, PDE6, and PDE9), and hydrolyzing both cAMP...
Trial of a Preferential Phosphodiesterase 4B Inhibitor for Idiopathic ...
WEBMay 15, 2022 · Phosphodiesterase 4 (PDE4) inhibition is associated with antiinflammatory and antifibrotic properties. 7,8 Preferential inhibition of the PDE4B subtype may be beneficial in the treatment of IPF...
PDE4 Inhibitors for Psoriasis: What to Know - Healthline
WEBApr 20, 2020 · How do they work for psoriasis? PDE4 inhibitors, like apremilast (Otezla), work inside the body to prevent inflammation. As a preventive measure, it may be beneficial for people with psoriasis to...
Phosphodiesterase-4 enzyme as a therapeutic target in …
WEBOct 1, 2020 · PDE4 enzyme is predominant amongst the 11 PDE super-family enzymes and has four isoforms - PDE4A, PDE4B, PDE4C and PDE4D. PDEs interact with myomegalin (a structural protein), which is highly expressed in skeletal and cardiac muscles and play crucial role in cardiac contractility [3].
Clinical Implication of Phosphodiesterase-4-Inhibition - PMC
WEBJan 21, 2022 · While there are many isotypes of PDE, a predominant role of PDE4 is to regulate fundamental functions, including endothelial and epithelial barrier stability, modulation of inflammatory responses and cognitive and/or mood functions. This makes the use of PDE4-I an interesting tool for various therapeutic approaches.
Inhibition of PDE4B suppresses inflammation by increasing
WEBApr 9, 2013 · Here, we show that inhibition of phosphodiesterase 4B (PDE4B) markedly enhances upregulation of CYLD expression in response to bacteria, thereby suggesting that PDE4B acts as a negative regulator...
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