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  1. Genetic mutations are changes to your DNA sequence that happen during cell division when your cells make copies of themselves. Your DNA tells your body how to form and function. Genetic mutations could lead to genetic conditions like cancer, or they could help humans better adapt to their environment over time.
    my.clevelandclinic.org/health/body/23095-genetic-…
    Mutations can result from errors in DNA replication during cell division, exposure to mutagens or a viral infection. Germline mutations (that occur in eggs and sperm) can be passed on to offspring, while somatic mutations (that occur in body cells) are not passed on.
    www.genome.gov/genetics-glossary/Mutation
    The human mutation rate is higher in the male germ line (sperm) than the female (egg cells), but estimates of the exact rate have varied by an order of magnitude or more. This means that a human genome accumulates around 64 new mutations per generation because each full generation involves a number of cell divisions to generate gametes.
    en.wikipedia.org/wiki/Mutation_rate
  2. People also ask
    Due to the combined action of hundreds of genes, mutation rates are extremely low–in humans, about one point mutation per 100 MB or about 60 genome-wide per generation ( Kong et al., 2012; Ségurel et al., 2014 ).
    More generally, whereas qualitative patterns of mutation rate variation on a megabase scale could not clearly be linked to molecular mechanisms 68, 69, models considering the sequence context and additional layers of information may help map mutational patterns to mechanisms.
    A mutated form of a gene is called a mutant allele. A gene is typically composed of a regulatory region, which is responsible for turning the gene’s transcription on and off at the appropriate times during development, and a coding region, which carries the genetic code for the structure of a functional molecule, generally a protein.
    Advanced: The research described here suggests that ancient humans’ use of fire favored individuals carrying a mutant AHR gene. Describe a few possible explanations for why the available Neanderthal sequences (which came from another fire-using lineage) did not have the mutant AHR gene.
  3. The mutations that make us human - Understanding Evolution

  4. Mutation | Definition, Causes, Types, & Facts | Britannica

    Web3 days ago · What are mutation hotspots? mutation, an alteration in the genetic material (the genome) of a cell of a living organism or of a virus that is more or less permanent and that can be transmitted to the cell’s or the …

  5. The causes of mutations - Understanding Evolution

  6. The origin of human mutation in light of genomic data

  7. The origins, determinants, and consequences of human mutations

  8. Genetic Mutation | Learn Science at Scitable - Nature

    WebWhile a mutation is defined as any alteration in the DNA sequence, biologists use the term "single nucleotide polymorphism " ( SNP) to refer to a single base pair alteration that is common in the...

  9. Rapid evolution of the human mutation spectrum - PMC

  10. The mutational landscape of human somatic and germline cells

  11. Hotspots of Human Mutation: Trends in Genetics - Cell …

    WebHotspots of Human Mutation. Highlights. Genetic mutations are influenced by sequence context, structure, and genomic features. Mechanisms responsible for many mutational hotspots have been identified. Hotspots …