ウェブDurham ( / ˈdʌrəm / DURR-əm) [11] is a city in the U.S. state of North Carolina and the county seat of Durham County. [12] Small portions of the city limits extend into Orange County and Wake County. With a population of 283,506 in the 2020 census, Durham is the 4th-most populous city in North Carolina, and the 71st-most populous ...