For years there was an intense debate as to whether the primary defect in type 2 diabetes (T2D) was insulin resistance or insulin secretory deficiency. This conflict has been resolved in that hyperglycemia only occurs when insulin secretion is insufficient

Guidelines have increasingly stressed the concept that adequate glycemic control is required to prevent or decrease the macro- and microvascular complications of type 2 diabetes mellitus (T2DM). PPAR-gamma agonists (“glitazones”) are no longer prioritized

2,4-Thiazolidinedione (TZD) is a privileged and highly utilised scaffold for the development of pharmaceutically active compounds. This sulfur-containing heterocycle is a versatile pharmacophore that confers a diverse range of pharmacological activities.

The thiazolidinediones (TZDs) or 'glitazones' are a new class of oral antidiabetic drugs that improve metabolic control in patients with type 2 diabetes through the improvement of insulin sensitivity. TZDs exert their antidiabetic effects through a mechanism

Thiazolidinones are an important class of heterocyclic compounds, derived from thiazolidine, which comprises an important family of heterocyclic compounds containing nitrogen and sulfur in a five membered ring. This family of compounds is considered highly