The PDE4 family of enzymes are the most prevalent PDE in immune cells. They are predominantly responsible for hydrolyzing cAMP within both immune cells and cells in the central nervous system.
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Phosphodiesterase-4 inhibitor
Drug class
A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 on cyclic adenosine monophosphate. It is a member of the larger family of PDE inhibitors. The PDE4... Wikipedia
Oct 17, 2018 · PDE4 inhibitors developed for the treatment of RA. Rheumatoic arthritis is a chronic, relapsed inflammatory autoimmune disease and is primarily ...
Aug 4, 2022 · Since the early 1980s, phosphodiesterase 4 (PDE4) has been an attractive target for the treatment of inflammation-based diseases.
PDE4 is an enzyme that helps to regulate inflammation in your body. When you have eczema, PDE4 enzymes may be overactive in your skin cells.
The cyclic nucleotide phosphodiesterase 4 (PDE4) family is a member of the larger cyclic nucleotide phosphodiesterase (Class I) superfamily of proteins. The ...
PDE4 inhibitors exhibit a range of actions upon cells of the immune system, both in vitro and in vivo, that suggest a possible therapeutic use for such drugs in ...
Mar 12, 2020 · Three PDE4 inhibitor drugs are currently approved for the treatment of skin or lung diseases: apremilast, crisaborole, and roflumilast.
Mar 6, 2024 · Crisaborole is FDA-approved to treat mild to moderate atopic dermatitis in both adults and kids. (Atopic dermatitis is classified as mild, ...
Apr 20, 2020 · PDE4 inhibitors are a new type of treatment for plaque psoriasis that prevents inflammation. Here's what you need to know.