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Between August and October of 1878, the disease killed more than 5,000 people. Towns along the railroads leading out of Memphis also experienced significant losses due to the epidemic. Yellow Fever caused fever, chills, hemorrhaging, severe pain, a yellowing of the skin, and vomit that was black in color.
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Lower Mississippi Valley yellow fever epidemic of 1878

In 1878, a severe yellow fever epidemic swept through the lower Mississippi Valley. Wikipedia
Start date: August 1878
In 1878, a severe yellow fever epidemic swept through the lower Mississippi Valley. "Tennessee-Memphis under quarantine rule; scenes in the plague-stricken ...
In August, 100 cases of yellow fever were reported in Grenada, Mississippi, about 100 miles south of Memphis. e_1878_03.jpg. Union Station, Memphis | Library of ...
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The yellow fever outbreak that hit Memphis in 1878 came north up the river from New Orleans. Before it had run its course, it also ravaged other cities, big and ...