Mitochondrial Medicine Therapies: Rationale, Evidence, and …
WEBSummary. We provide a comprehensive update on mitochondrial medicine therapies based on current evidence and our single-center clinical experience to support or refute their use, and provide detailed dosing guidelines, for the clinical management of mitochondrial disease.
Mitochondrial Medicine Program - Children's Hospital of Philadelphia
WEBThe Mitochondrial Medicine Program, a Frontier Program at Children's Hospital of Philadelphia, focuses on identifying the underlying cause of mitochondrial disease, difficult-to-treat genetic-based energy disorders.
Mitochondrial disorders and drugs: what every physician should …
WEBJul 4, 2019 · Introduction. Mitochondrial disorders (MD) are an extraordinarily complex group of diseases caused by impairment of mitochondrial functions, especially of the mitochondrial respiratory chain. 1 Mitochondria are dynamic organelles whose maintenance requires about 1500 proteins.
A Modern Approach to the Treatment of Mitochondrial Disease
WEBTreatment of mitochondrial disease is still in its infancy. Aside from symptom-based management, treatment of mitochon-drial disease focuses on maintaining optimal health, using preventive measures to mitigate symptom worsening during times of physiologic stress (such as infection, dehydration, or surgery), and avoiding mitochondrial toxins.
Mitochondrial dysfunction: mechanisms and advances in therapy
WEB4 days ago · The early trajectory of mitochondrial medicine was anchored on the correlation of clinical symptoms with aberrant mitochondrial biochemical signatures and morphological anomalies, as demonstrated ...
Pharmacological advances in mitochondrial therapy
WEBFeb 26, 2021 · Here, we will describe the most promising therapeutic strategies, which can be divided into three major classes: (i) targeted and (ii)untargeted mitochondrial drugs, and inhibitors of mitochondrial translation (iii).
Diagnosis and management of mitochondrial disease: a …
WEBDec 11, 2014 · Abstract. Purpose: The purpose of this statement is to review the literature regarding mitochondrial disease and to provide recommendations for optimal diagnosis and treatment. This statement is...
Applying genomic and transcriptomic advances to mitochondrial medicine ...
WEBFeb 23, 2021 · Mitochondrial medicine is poised to benefit substantially from the increasing use of RNA sequencing of tissue samples; advances in pre-processing and sequencing of transfer RNA are enabling new...
Novel targets for mitochondrial medicine | Science Translational Medicine
WEBWe present possible new druggable targets in mitochondrial biology, including protein modification, calcium ion (Ca 2+) transport, and dynamics, as we move into a new era of mitochondrial medicine. As the powerhouse of the cell, …
Mitochondrial Medicine | CHOP Research Institute
WEBMitochondrial Medicine. Share: Watch this page. Mitochondria function as the biological batteries that produce energy within our body's cells.
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