Glutamate is formed directly from glutamine by deamidation via phosphate activated glutaminase a reaction that also yields ammonia. Glutamate plays key roles linking carbohydrate and amino acid metabolism via the tricarboxylic acid (TCA) cycle, as well as in nitrogen trafficking and ammonia homeostasis in brain.
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Glutamate is a nonessential amino acid that does not cross the blood-brain barrier and must be synthesized in neurons from local precursors. The most prevalent ...
Glutamate is synthesized in the central nervous system from glutamine as part of the glutamate–glutamine cycle by the enzyme glutaminase. This can occur in the ...
It appears that glutamate formed from glutamine may be metabolized in the tricarboxylic acid (TCA) cycle prior to its conversion to GABA, which may allow new ...
Glutamate is synthesized from glutamine by glutaminase, the rate-limiting step in the pathway. Glutamate is then packaged into vesicles by vesicular glutamate ...
Glutamic acid is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins. It is a non-essential nutrient for humans, ...
Glutamate is the final product of arginine, proline, and probably ornithine catabolism (7). Furthermore, transaminases can transfer the amino group of aspartate ...
Duration: 1:59
Posted: Apr 13, 2018
Posted: Apr 13, 2018
Sep 15, 2021 · The two primary enzymes mediating glutamate synthesis and metabolism in the brain are aspartate aminotransferase (AAT) and glutamate ...